Mariën K
Washington State Department of Health, Olympia 98504, USA.
Environ Health Perspect. 1996 Nov;104(11):1230-6. doi: 10.1289/ehp.104-1469507.
Domoic acid has been found in razor clams (Siliqua patula) and dungeness crabs (Cancer magister) in Washington State and elsewhere on the West Coast of the United States. Due to toxic effects associated with domoic acid exposure, an effort has been made to establish tolerable domoic acid levels in crabs and clams obtained from commercial harvest and sale and from individual recreational harvesting. To accomplish this, the amount of clams and crabs consumed by populations of concern was determined, a tolerable daily intake (TDI) was developed for individuals most sensitive to effects of this compound, and the TDI was equated with consumption patterns to determine tolerable clam and crab domoic acid levels. Results indicate that the primary health effects associated with domoic acid toxicity can be averted in populations of concern and for others consuming crabs or clams less frequently (or in lesser quantity) if domoic acid contaminant concentration does not exceed 30 mg/kg in the hepatopancreas and viscera of dungeness crabs or 20 mg/kg in clams.
在美国华盛顿州以及西海岸其他地区的剃刀蛤（Siliqua patula）和邓杰内斯蟹（Cancer magister）中发现了软骨藻酸。由于接触软骨藻酸会产生毒性作用，人们已努力确定从商业捕捞和销售以及个人休闲捕捞获得的螃蟹和蛤中可耐受的软骨藻酸水平。为此，确定了相关人群食用的蛤和蟹的数量，为对该化合物影响最敏感的个体制定了每日可耐受摄入量（TDI），并将TDI与消费模式等同起来，以确定蛤和蟹中可耐受的软骨藻酸水平。结果表明，如果邓杰内斯蟹肝胰腺和内脏中的软骨藻酸污染物浓度不超过30毫克/千克，或者蛤中的浓度不超过20毫克/千克，那么相关人群以及其他较少食用（或食用量较少）螃蟹或蛤的人，与软骨藻酸中毒相关的主要健康影响是可以避免的。
