Lutsyk M D, Lutsyk A D, Kipiani E K, Krupko A E
Neoplasma. 1977;24(3):341-3.
Lectins from Ricinus communis seeds (RCL) have been resolved into three electrophoretically distinct fractions (alpha-RCL, beta-RCL, psi-RCL) by ion exchange chromatography on Watman CM-32 cellulose. The toxicity to mice and antitumor activity against murine lymphoma NK/Ly of pure fractions were compared. Optimal effect was achieved with alpha-RCL, Which possessed the lowest toxicity (1000 micron g/kg) and significant antitumor activity (63% inhibition of tumor growth).
蓖麻籽中的凝集素（RCL）通过在沃特曼CM - 32纤维素上进行离子交换色谱法已被分离为三个电泳性质不同的组分（α - RCL、β - RCL、ψ - RCL）。比较了纯组分对小鼠的毒性以及对小鼠淋巴瘤NK/Ly的抗肿瘤活性。α - RCL取得了最佳效果，其毒性最低（1000微克/千克）且具有显著的抗肿瘤活性（肿瘤生长抑制率为63%）。
