关于肼屈嗪诱导的致突变性和遗传毒性机制的研究。
Studies on the mechanism of hydralazine induced mutagenicity and genotoxicity.
作者信息
Chopkiewicz B, Ejchart A, Marczewska J
机构信息
Drug Institute, Warsaw, Poland.
出版信息
Acta Pol Pharm. 1995 May-Jun;52(3):219-22.
The mutagenicity (Ames test) and genotoxicity (SOS Chromotest) of hydralazine were studied. Hydralazine was found to be genotoxic to E.coli PQ37. In experiments with E.coli MD332 it was genotoxic in responsive temperature (30 degrees C) but not genotoxic in non-responsive temperature (42 degrees C). Hydralazine was mutagenic to S.typhimurium TA100 and TA104 but not mutagenic to TA102. Different active oxygen species scavengers did not influence the genotoxicity and mutagenicity of hydralazine.
研究了肼屈嗪的致突变性（艾姆斯试验）和遗传毒性（SOS色变试验）。发现肼屈嗪对大肠杆菌PQ37具有遗传毒性。在大肠杆菌MD332的实验中，它在响应温度（30摄氏度）下具有遗传毒性，但在非响应温度（42摄氏度）下无遗传毒性。肼屈嗪对鼠伤寒沙门氏菌TA100和TA104具有致突变性，但对TA102无致突变性。不同的活性氧清除剂不影响肼屈嗪的遗传毒性和致突变性。
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