Vaillant M C, Chantepie A, Casasoprana A, Chamboux C, Suc A L, Gold F, Laugier J
Department of Pediatric Cardiology, University Hospital Clocheville, Tours, France.
Pediatr Cardiol. 1997 Jan-Feb;18(1):52-6. doi: 10.1007/s002469900110.
We report three cases of transient myocardial hypertrophy, diagnosed by echocardiography, occurring between the second and seventh days of life in neonates with initially normal ventricular myocardial wall thickness. The three term neonates had perinatal injury with acute fetal distress. In all three cases electrocardiographic and biologic signs of myocardial ischemia were present. The first echocardiographic results showed abnormalities in systolic or diastolic left ventricular function, without hypertrophy of the walls. The hypertrophic cardiomyopathy (HCM) occurred between days 2 and 7 and affected first the interventricular septum and the free wall of the right ventricle. The left ventricular posterior wall subsequently became abnormal, resulting in severe overall myocardial hypertrophy, which finally disappeared in all three cases between 1 and 5 months of life. Such observations of early severe and transient HCM have not been previously reported. We believe it is a consequence of myocardial ischemia due to acute fetal distress. The prognosis of this type of HCM is good, in contrast to that of other primitive HCM occurring in neonates.
我们报告了三例经超声心动图诊断的短暂性心肌肥厚病例，这些病例发生在出生时心室心肌壁厚度最初正常的新生儿出生后第2天至第7天之间。这三名足月儿有围产期损伤并伴有急性胎儿窘迫。在所有三例中，均存在心肌缺血的心电图和生物学体征。最初的超声心动图结果显示左心室收缩或舒张功能异常，但无心肌壁肥厚。肥厚型心肌病（HCM）在第2天至第7天出现，首先累及室间隔和右心室游离壁。随后左心室后壁出现异常，导致严重的整体心肌肥厚，最终这三例在出生后1至5个月内均消失。此前尚未有过这种早期严重且短暂性HCM的相关报道。我们认为这是急性胎儿窘迫导致心肌缺血的结果。与新生儿中出现的其他原发性HCM不同，这种类型的HCM预后良好。
