Samii A, Wassermann E M, Ikoma K, Mercuri B, George M S, O'Fallon A, Dale J K, Straus S E, Hallett M
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1428, USA.
Neurology. 1996 Dec;47(6):1410-4. doi: 10.1212/wnl.47.6.1410.
We studied the effects of exercise on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in 18 normal (control) subjects, 12 patients with chronic fatigue syndrome, and 10 depressed patients. Subjects performed repeated sets of isometric exercise of the extensor carpi radialis muscle until they were unable to maintain half maximal force. MEPs were recorded before and after each exercise set and for up to 30 minutes after the last set. The mean amplitude of MEPs recorded from the resting muscle immediately after each exercise set was 218% of the mean pre-exercise MEP amplitude in normal subjects, 126% in chronic fatigue patients, and 155% in depressed patients, indicating postexercise MEP facilitation in all three groups. The increases in the patient groups, however, were significantly lower than normal. The mean amplitudes of MEPs recorded within the first few minutes after the last exercise sets in all three groups were approximately half their mean pre-exercise MEP amplitudes. This postexercise MEP depression was similar in all groups. We conclude that postexercise cortical excitability is significantly reduced in patients with chronic fatigue syndrome and in depressed patients compared with that of normal subjects.
我们研究了运动对18名正常（对照）受试者、12名慢性疲劳综合征患者和10名抑郁症患者经颅磁刺激（TMS）诱发的运动诱发电位（MEP）的影响。受试者对桡侧腕伸肌进行重复的等长运动，直至无法维持最大力量的一半。在每组运动前后以及最后一组运动后长达30分钟内记录MEP。每组运动后立即从静息肌肉记录的MEP平均波幅在正常受试者中为运动前MEP平均波幅的218%，在慢性疲劳患者中为126%，在抑郁症患者中为155%，表明三组患者运动后MEP均出现易化。然而，患者组的增加幅度明显低于正常组。在最后一组运动后的最初几分钟内，三组记录的MEP平均波幅约为运动前MEP平均波幅的一半。这种运动后MEP抑制在所有组中相似。我们得出结论，与正常受试者相比，慢性疲劳综合征患者和抑郁症患者运动后皮质兴奋性显著降低。
