Cameron M M, Haas R H
Acta Neurochir (Wien). 1976;34(1-4):261-4. doi: 10.1007/BF01405881.
Over the last 15 years progressive interest has developed in the relationship between subarachnoid haemorrhage, sympathetic nervous system over-activity and the genesis of cerebral artery spasm. Following on from earlier work, vide infra, suggesting that adrenergic blockade might influence the course and prognosis of patients with subarachnoid haemorrhage, two double blind trials have recently been completed in Southampton. The first trial attempted to establish whether or not a single intracarotid injection of phenoxybenzamine improved the mortality and late morbidity of patients with subarachnoid haemorrhage. Results suggested that it did not. The second trial, comprising two groups of 50 patients each, attempted to assess the influence of prolonged treatment with propranolol on the course and prognosis of these subarachnoid haemorrhage patients. Early results suggest that, as with the alpha-blocker, the mortality and severe morbidity was not improved by beta-adrenergic blockade.
在过去15年里，人们对蛛网膜下腔出血、交感神经系统过度活跃与脑动脉痉挛的发生之间的关系越来越感兴趣。继早期的研究工作（见下文）表明肾上腺素能阻滞剂可能影响蛛网膜下腔出血患者的病程和预后之后，南安普敦最近完成了两项双盲试验。第一项试验试图确定经颈动脉单次注射酚苄明是否能改善蛛网膜下腔出血患者的死亡率和后期发病率。结果表明不能。第二项试验每组有50名患者，试图评估普萘洛尔长期治疗对这些蛛网膜下腔出血患者病程和预后的影响。早期结果表明，与α受体阻滞剂一样，β肾上腺素能阻滞剂并不能改善死亡率和严重发病率。
