Sarica K, Koşar A, Yaman O, Bedük Y, Durak I, Göğüş O, Kavukçu M
Department of Urology, Ibn-i Sina Hospital, University of Ankara Medical School, Turkey.
Urol Int. 1996;57(4):221-3. doi: 10.1159/000282918.
To evaluate the degree of ischemic formation at the tissue level after high-energy shock wave (HESW) application in a time- and dose-dependent manner, an experimental study in rabbits was performed. Following varying numbers of HESWs (1,000-2,000-3,000 shock waves) under fluoroscopic localization, treated kidneys were removed, by assessing tissue concentrations of two different free-radical scavenger enzymes (superoxide dismutase and catalase) the degree of formation of free oxygen radicals (i.e. ischemia) was evaluated. Evaluation of our results showed a statistically significant (p < 0.05) decrease in tissue scavenger enzyme levels (i.e. formation of free oxygen radicals) after 24 h following HESW application. However, results obtained 7 days after ESWL demonstrated disappearance of ischemia with normalization of tissue enzyme levels (p > 0.05).
为了以时间和剂量依赖的方式评估高能冲击波（HESW）应用后组织水平的缺血形成程度，在兔子身上进行了一项实验研究。在透视定位下施加不同数量的HESW（1000 - 2000 - 3000次冲击波）后，切除处理过的肾脏，通过评估两种不同的自由基清除酶（超氧化物歧化酶和过氧化氢酶）的组织浓度来评估游离氧自由基的形成程度（即缺血程度）。对我们结果的评估显示，在应用HESW后24小时，组织清除酶水平（即游离氧自由基的形成）有统计学意义的显著下降（p < 0.05）。然而，体外冲击波碎石术（ESWL）7天后获得的结果表明缺血消失，组织酶水平恢复正常（p > 0.05）。
