Tong Y C, Hung Y C, Lin S N, Cheng J T
Department of Urology, National Cheng Kung, University Medical College, Tainan, Taiwan, Republic of China.
Urol Int. 1996;57(4):230-4. doi: 10.1159/000282921.
The treatment effect of "ryu-wei-ti-huang-wan', a Chinese prescription composed of extracts from six plants, on diabetic impotence was evaluated in the present study. Adult male Wistar rats were divided into three groups: (1) rats rendered diabetic with a single intraperitoneal injection of streptozotocin (60 mg/kg body weight); (2) rats with streptozotocin-induced diabetes treated with a ryu-wei-ti-huang-wan powder preparation at a dose of 30 mg powder/kg body weight twice a day, and (3) control rats. A male rat was caged with an adult ovariectomized female rat during the dark cycle. Infra-red-light-illuminated video recording was utilized to evaluate the sexual performance. The diabetic rats exhibited depressed mounting activity and no intromission or ejaculation. After ryu-wei-ti-huang-wan treatment either for 1 day or 2 weeks, the diabetic rats showed significant improvement in mounting performance with preservation of intromission and ejaculation. No significant difference in the blood sugar level was noted between the treatment and non-treatment groups. In conclusion, the diabetic rats showed impairment in sexual arousal, erectile as well as ejaculatory functions. Ryu-wei-ti-huang-wan was effective in preserving these functions with a rapid onset. It is evident that the extracts exert the therapeutic effects not through a lowering of blood sugar. These substances are potentially useful in the clinical treatment of male diabetic impotence.
本研究评估了由六种植物提取物组成的中药方剂“六味地黄丸”对糖尿病性阳痿的治疗效果。成年雄性Wistar大鼠分为三组：（1）单次腹腔注射链脲佐菌素（60mg/kg体重）致糖尿病的大鼠；（2）链脲佐菌素诱导糖尿病的大鼠，用六味地黄丸散剂按30mg散剂/kg体重每天两次进行治疗；（3）对照大鼠。在黑暗周期将一只雄性大鼠与一只成年去卵巢雌性大鼠关在一个笼子里。利用红外光照射视频记录来评估性行为表现。糖尿病大鼠表现出爬跨活动减少，无插入或射精。六味地黄丸治疗1天或2周后，糖尿病大鼠的爬跨表现有显著改善，保留了插入和射精功能。治疗组和未治疗组之间血糖水平无显著差异。总之，糖尿病大鼠在性唤起、勃起以及射精功能方面存在损害。六味地黄丸能有效保留这些功能且起效迅速。显然，提取物并非通过降低血糖发挥治疗作用。这些物质在男性糖尿病性阳痿的临床治疗中可能有用。
