Gibbs C P, Meyer T F
Max-Planck-Institut für Biologie, Abteilung Infektionsbiologie, Tübingen, Germany.
FEMS Microbiol Lett. 1996 Dec 1;145(2):173-9. doi: 10.1111/j.1574-6968.1996.tb08574.x.
The pathogenic Neisseria have exploited the processes of horizontal DNA transfer and genetic recombination as mechanisms for the generation of extensive protein variation and modulation of gene expression. Localized recombinations have been well documented in members of multigene families as have alterations in short repetitive sequences. Here we report an analysis of the chromosomal structure of a defined lineage of Neisseria gonorrhoeae strain MSl1 pilin variants. This study reveals the occurrence of large rearrangements, including the amplification of a 26 kb region and an inversion involving more than a third of the chromosome. Additionally, a restriction site polymorphism that correlates with pilin expression has been observed. These findings highlight the flexibility of the gonococcal genome.
致病性奈瑟菌利用水平DNA转移和基因重组过程作为产生广泛蛋白质变异和调节基因表达的机制。多基因家族成员中的局部重组以及短重复序列的改变都有充分的文献记载。在此，我们报告了对淋病奈瑟菌菌株MSl1菌毛蛋白变体特定谱系的染色体结构分析。这项研究揭示了大规模重排的发生，包括一个26 kb区域的扩增和涉及超过三分之一染色体的倒位。此外，还观察到一个与菌毛蛋白表达相关的限制性位点多态性。这些发现突出了淋球菌基因组的灵活性。
