Tan M H, Commens C A, Burnett L, Snitch P J
Department of Dermatology, Westmead Hospital, New South Wales, Australia.
Australas J Dermatol. 1996 Nov;37(4):185-7. doi: 10.1111/j.1440-0960.1996.tb01050.x.
Many Australians are being advised to apply microfine titanium dioxide sunscreen daily from the cradle to the grave. However, there is a surprising lack of data on the percutaneous absorption of microfine titanium dioxide. A prospective pilot study was conducted to analyse the percutaneous absorption of microfine titanium dioxide from sunscreens. Selected patients scheduled to have skin surgery, applied titanium dioxide sunscreen to the skin daily for 2-6 weeks prior to their operation. After excision, the stratum corneum of the sample was stripped and the titanium concentration of the remaining epidermis and dermis was measured by inductively coupled plasma-mass spectrometry. The results from this pilot study showed that levels of titanium in the epidermis and dermis of subjects who applied microfine titanium dioxide to their skin were higher than the levels of titanium found in controls. Studies with larger cohorts are necessary to establish if this absorption is statistically significant.
许多澳大利亚人被建议从摇篮到坟墓每天都涂抹超细二氧化钛防晒霜。然而，关于超细二氧化钛经皮吸收的数据却惊人地匮乏。开展了一项前瞻性试点研究，以分析防晒霜中超细二氧化钛的经皮吸收情况。选定计划进行皮肤手术的患者，在手术前2至6周每天在皮肤上涂抹二氧化钛防晒霜。切除后，剥去样本的角质层，通过电感耦合等离子体质谱法测量剩余表皮和真皮中的钛浓度。这项试点研究的结果表明，在皮肤上涂抹超细二氧化钛的受试者的表皮和真皮中的钛含量高于对照组中发现的钛含量。需要进行更大样本量的研究来确定这种吸收是否具有统计学意义。
