Calgüneri M, Kiraz S, Ertenli I, Benekli M, Karaarslan Y, Celik I
Hacettepe University, Ankara, Turkey.
Arthritis Rheum. 1996 Dec;39(12):2062-5. doi: 10.1002/art.1780391216.
Because exposure to streptococcal antigens might be a major disease activity-provoking factor in Behçet's disease, this study was undertaken to evaluate the effectiveness of benzathine penicillin in the prophylaxis of recurrent arthritis episodes during the course of this disease.
A prospective, randomized study design was used to allocate patients to receive colchicine alone or colchicine plus benzathine penicillin for 24 months.
The duration, severity, and pattern of arthritis episodes were found to be similar in the 2 treatment groups, but the number of arthritis episodes was significantly reduced, and the duration of episode-free time significantly prolonged, in the penicillin group compared with the colchicine-alone group.
Penicillin treatment was demonstrated to offer adjunctive benefits in the prevention of arthritis episodes which are not obtainable with colchicine monotherapy. This finding could provide additional evidence for antigen triggering in the pathogenesis of Behçet's disease.
由于暴露于链球菌抗原可能是白塞病中引发主要疾病活动的因素，因此开展本研究以评估苄星青霉素在预防该病病程中复发性关节炎发作方面的有效性。
采用前瞻性随机研究设计，将患者分配为单独接受秋水仙碱治疗或接受秋水仙碱加苄星青霉素治疗24个月。
发现两个治疗组中关节炎发作的持续时间、严重程度和发作模式相似，但与单独使用秋水仙碱组相比，青霉素组的关节炎发作次数显著减少，无发作时间显著延长。
已证明青霉素治疗在预防关节炎发作方面具有辅助益处，这是秋水仙碱单一疗法无法实现的。这一发现可为白塞病发病机制中的抗原触发提供更多证据。
