Vittecoq O, Mejjad O, da Silva F, Joly P, Thomine E, Lauret P, Thomine J M, le Loët X
Hôpital de Boisguillaume, CHU de Rouen, France.
Arthritis Rheum. 1996 Dec;39(12):2070-3. doi: 10.1002/art.1780391218.
Fibroblastic rheumatism (FR) is a rare disease characterized by joint manifestations without joint destruction, and associated with cutaneous nodules and sclerodactyly. The diagnosis is usually based on histologic examination of a skin nodule or synovium specimen. In the 11 previously reported cases, corticosteroid treatment, which has been widely used, was shown to have an unpredictable effect on the evolution of FR. We report a case of FR that was treated with methotrexate for 5 years, which led to complete recovery. This drug may be considered an effective treatment for FR. Further cases are needed to confirm this preliminary experience.
纤维母细胞性风湿病（FR）是一种罕见疾病，其特征为有关节表现但无关节破坏，且与皮肤结节和指（趾）硬皮病相关。诊断通常基于皮肤结节或滑膜标本的组织学检查。在先前报道的11例病例中，广泛使用的糖皮质激素治疗对FR的病程显示出不可预测的效果。我们报告1例接受甲氨蝶呤治疗5年的FR病例，该病例实现了完全康复。该药可被视为FR的有效治疗方法。需要更多病例来证实这一初步经验。
