质子沿蛋白质单层的长程迁移及其对膜偶联的影响。
Proton long-range migration along protein monolayers and its consequences on membrane coupling.
作者信息
Gabriel B, Teissié J
机构信息
Institut de Pharmacologie et de Biologie Structurale-Centre National de la Recherche Scientifique, Toulouse, France.
出版信息
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14521-5. doi: 10.1073/pnas.93.25.14521.
Abstract
It has been shown with lipid layers and more recently with purple membranes that protons have slow surface-to-bulk transfer. This results in long-range proton lateral conduction along membranes. We report here that such lateral transfer can take place along a pure protein film. It is strongly controlled by the packing. Subtle reorganizations of the protein-protein contact can be biological switches between interfacial and delocalized proton pathways between sources and sinks.
摘要
脂质层以及最近的紫色膜实验均表明，质子在表面到本体的转移过程较为缓慢。这导致质子沿着膜进行长距离的横向传导。我们在此报告，这种横向转移能够沿着纯蛋白质膜发生。它受到堆积的强烈控制。蛋白质与蛋白质接触的细微重组可能是源与汇之间界面质子途径和离域质子途径的生物开关。
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