Silverstein Todd P
Department of Chemistry, Willamette University, Salem, OR, 97301, USA.
J Bioenerg Biomembr. 2022 Apr;54(2):59-65. doi: 10.1007/s10863-022-09931-w. Epub 2022 Feb 21.
In his Transmembrane Electrostatically Localized Proton hypothesis (TELP), James W. Lee has modeled the bioenergetic membrane as a simple capacitor. According to this model, the surface concentration of protons is completely independent of proton concentration in the bulk phase, and is linearly proportional to the transmembrane potential. Such a proportionality runs counter to the results of experimental measurements, molecular dynamics simulations, and electrostatics calculations. We show that the TELP model dramatically overestimates the surface concentration of protons, and we discuss the electrostatic reasons why a simple capacitor is not an appropriate model for the bioenergetic membrane.
在其跨膜静电定位质子假说（TELP）中，詹姆斯·W·李将生物能膜模拟为一个简单的电容器。根据该模型，质子的表面浓度完全独立于本体相中的质子浓度，并且与跨膜电位呈线性比例关系。这种比例关系与实验测量、分子动力学模拟和静电学计算的结果相悖。我们表明，TELP模型极大地高估了质子的表面浓度，并讨论了为何简单电容器不是生物能膜合适模型的静电学原因。
