Mechanism of action of hemolysin III from Bacillus cereus.
作者信息
Baida G E, Kuzmin N P
机构信息
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
出版信息
Biochim Biophys Acta. 1996 Oct 23;1284(2):122-4. doi: 10.1016/s0005-2736(96)00168-x.
PMID:8962879
Abstract
Bacillus cereus hemolysin III activity was tested in crude extracts, from Escherichia coli carrying the hly-III gene. It was concluded that hemolysin III is a pore-forming hemolysin with functional pore diameter of about 3-3.5 nm. Hemolysis occurs in at least three steps: (i) the temperature-dependent binding of the Hly-III monomers to the erythrocyte membrane; (ii) the temperature-dependent formation of the transmembrane oligomeric pore; (iii) the temperature-independent erythrocyte lysis.
摘要
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