Hamm W, Richardsen G, Switkowski R
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universität zu Köln.
Z Geburtshilfe Neonatol. 1996 May-Jun;200(3):115-8.
Lactate dehydrogenase (LDH) isoenzymes were serially measured in nine patients with HELLP syndrome during 01. 01. 1994-31. 01. 1995; at the time of the maxima of the total LDH we observed in 8/9 cases an absolute and relative maximum of LDH isoenzyme 5, that predominantly originates from the liver and from skeleton muscles, with coincident relative decrease of LDH isoenzymes 1 and 2, which are the predominant forms in heart muscle and erythrocytes. Therefore, total LDH can not be used as a marker of intravascular hemolysis in HELLP syndrome. The most sensitive marker for the hemolytic component of HELLP syndrome is the measurement of haptoglobin which should be included in laboratory screening in all cases with suspected HELLP syndrome.
1994年1月1日至1995年1月31日期间，对9例HELLP综合征患者连续检测乳酸脱氢酶（LDH）同工酶；在总LDH达到最大值时，我们发现9例中有8例LDH同工酶5出现绝对和相对最大值，该同工酶主要来源于肝脏和骨骼肌，同时LDH同工酶1和2相对减少，这两种同工酶是心肌和红细胞中的主要形式。因此，总LDH不能用作HELLP综合征血管内溶血的标志物。HELLP综合征溶血成分最敏感的标志物是血清结合珠蛋白的测定，所有疑似HELLP综合征的病例在实验室筛查中都应检测该指标。
