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[HELLP综合征的诊断问题——参考20例病例报告]

[Diagnostic problems in HELLP syndrome--presented with reference to 20 case reports].

作者信息

Salfelder A, Kagerah M, Nugent W, Blees M

机构信息

Frauenklinik Finkenau, Hamburg.

出版信息

Zentralbl Gynakol. 1993;115(10):433-45.

PMID:8273433
Abstract

15 so-called "definite" cases and five so-called "questionable" cases of HELLP-Syndrome are reported and discussed. The cases demonstrate the chameleon-like behaviour of symptoms and how difficult it can be to avoid it's full manifestation even if careful attention is paid to liver enzymes or platelets. Elevated liver enzymes and low platelets are also found in normal pregnancies making differential diagnosis more difficult as the retrospective analysis of laboratory findings of more than 2000 normal pregnancies shows. Even though, careful attention should be paid to detect any early laboratory finding or clinical sign of HELLP-Syndrome in order to prevent dramatic outcomes. Any symptoms of gestosis should be reason to determine not only liver enzymes and platelets, but also haptoglobin as the latter seems to detect early hemolysis in a beginning HELLP-Syndrome.

摘要

本文报告并讨论了15例所谓“确诊”的HELLP综合征病例和5例所谓“可疑”病例。这些病例展示了症状如变色龙般的表现,以及即便密切关注肝酶或血小板,避免其全面发作仍有多困难。超过2000例正常妊娠的实验室检查结果回顾性分析显示,正常妊娠中也会出现肝酶升高和血小板减少的情况,这使得鉴别诊断更加困难。尽管如此,仍应密切关注,以检测出HELLP综合征的任何早期实验室检查结果或临床体征,从而预防严重后果。任何妊娠中毒症状都应促使医生不仅要测定肝酶和血小板,还要测定触珠蛋白,因为后者似乎能检测出早期HELLP综合征中的溶血情况。

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