Paulus U, Körtje K H, Slenzka K, Rahmann H
Institute of Zoology, University of Stuttgart-Hohenheim, Germany.
J Hirnforsch. 1996;37(1):103-7.
The mitochondrial enzyme, cytochrome oxidase, was localized cytochemically in the nucleus magnocellularis, a primary relay nucleus of vestibular information within the area octavolateralis in the fish brain. Cichlid fish larvae were analyzed after long-term exposure (9 days) to altered gravity situations: increased acceleration in a centrifuge (3 g) and near weightlessness during space flight. Controls (1 g) were reared under identical conditions in the centrifuge but without rotation on earth or with an acceleration resulting in gravity of 1 g in space shuttle. Quantification of highly reactive mitochondria reveals a correlation of gravity and cytochrome oxidase activity: low enzyme activity in respect to 1 g controls under near weightlessness conditions and an increased activity after hyper-g exposure in a centrifuge. This gravity effect on the energy metabolism of vestibular nuclei of developing cichild fish seems to reflect adaptational processes in response to gravity stimulation.
线粒体酶细胞色素氧化酶，通过细胞化学方法定位在鱼脑八侧区的前庭信息主要中继核——巨细胞核中。对丽鱼科幼鱼进行长期暴露（9天）于改变的重力环境后的分析：在离心机中增加加速度（3g）以及在太空飞行期间接近失重状态。对照组（1g）在地球上离心机中相同条件下饲养，但不旋转，或在航天飞机中以产生1g重力的加速度饲养。对高活性线粒体的定量分析揭示了重力与细胞色素氧化酶活性之间的相关性：在接近失重条件下相对于1g对照组酶活性较低，而在离心机中进行超重力暴露后活性增加。这种重力对发育中的丽鱼科鱼前庭核能量代谢的影响似乎反映了对重力刺激的适应性过程。
