Velasco M, Rodriguez I
Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas.
J Hum Hypertens. 1996 Feb;10 Suppl 1:S77-80.
A modern approach to the choice of antihypertensive therapy is discussed in this article. Since the introduction of hydralazine and reserpine in 1950, a number of compounds have been proposed for the treatment of hypertension. The 1993 report of the Joint National Committee on Hypertension established four choices: diuretics, beta blockers, ACEIs, and calcium entry blockers. Additionally, alpha and alpha-beta blockers were also recommended. Several pharmacological considerations have been discussed concerning medical therapy of hypertension. In modern therapy, the best approach is individualized therapy, in which three major principles are taken into consideration: (1) The use of diuretics, alpha blockers, beta blockers, ACEIs, or calcium entry blockers, (2) The presence of concomitant diseases, and (3) The use of substitution therapy. Several other factors are discussed such as the cost of medication, drug interactions and combinational therapy.
本文讨论了抗高血压治疗选择的现代方法。自1950年引入肼屈嗪和利血平以来，已提出多种化合物用于治疗高血压。1993年美国国家高血压联合委员会的报告确定了四种选择：利尿剂、β受体阻滞剂、血管紧张素转换酶抑制剂（ACEIs）和钙通道阻滞剂。此外，还推荐了α受体阻滞剂和α-β受体阻滞剂。已经讨论了关于高血压药物治疗的一些药理学考虑因素。在现代治疗中，最佳方法是个体化治疗，其中考虑三个主要原则：（1）使用利尿剂、α受体阻滞剂、β受体阻滞剂、ACEIs或钙通道阻滞剂；（2）并存疾病的存在；（3）使用替代疗法。还讨论了其他一些因素，如药物成本、药物相互作用和联合治疗。
