Leuppi J D, Hartmann K, Ciociaro C, Reinhart W H, Kuhn M
Medizinische Klinik, Kantonsspital Chur.
Praxis (Bern 1994). 1996 Oct 29;85(44):1394-7.
Between 1991 and 1995 about 3% of the unwanted drug-induced side effects reported to the Swiss Drug Monitoring Center (SANZ) concerned pulmonary disturbances (144 out of a total of 4824 reports). The most frequent reports were those about cough and taste disorders caused by ACE-inhibitors, smell disorders caused by antimicotics, and asthma attacks caused by nonsteroidal antirheumatics or betablocking eye drops. 33% of these unwanted side effects have been classified as severe. By spontaneous reporting a correct calculation of incidence is not possible. The reports, however, have signal function. Precise case analysis, temporary correlations (reaction and exposure time and onset of reaction), exclusion of other causes for the disease, comparisons between similar cases and critical study of literature concerning drug-related side effects are still the most important foundations for diagnosis.
1991年至1995年间，向瑞士药物监测中心（SANZ）报告的不良药物副作用中，约3%涉及肺部紊乱（在总共4824份报告中有144份）。最常见的报告是关于ACE抑制剂引起的咳嗽和味觉障碍、抗真菌药引起的嗅觉障碍，以及非甾体类抗风湿药或β受体阻滞剂眼药水引起的哮喘发作。这些不良副作用中33%被归类为严重。通过自发报告无法正确计算发病率。然而，这些报告具有信号功能。精确的病例分析、时间相关性（反应与暴露时间及反应 onset）、排除疾病的其他病因、相似病例之间的比较以及对药物相关副作用文献的批判性研究仍然是诊断的最重要基础。 （注：原文中“onset of reaction”的“onset”未准确翻译，可能影响理解，大致意思是反应的起始情况等）
