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在体重指数正常但体型不同的人群中,冠心病危险因素及脂肪肝患病率是否存在差异?

Is there any difference in coronary heart disease risk factors and prevalence of fatty liver in subjects with normal body mass index having different physiques?

作者信息

Hsieh S D, Yoshinaga H

机构信息

Medical Center of Health Science, Toranomon Hospital, Tokyo, Japan.

出版信息

Tohoku J Exp Med. 1995 Nov;177(3):223-31. doi: 10.1620/tjem.177.223.

Abstract

Levels of coronary heart disease (CHD) risk factors such as systolic and diastolic blood pressure, fasting blood glucose, hemoglobin A1c, triglyceride, cholesterol, HDL-cholesterol, prevalence of hypertension, abnormal glucose tolerance, hypertriglyceridemia, hypercholesterolemia, low HDL-cholesterol level, and fatty liver in normal body mass index (BMI) subjects with high or low waist/height ratios were investigated in middle aged men (45-54 years, BMI: 22-23.2 kg/m2) undergoing a routine health examination. The subjects were divided into two groups according to whether their waist/height ratios were > or = 0.5 (n = 131) or < 0.5 (n = 121). There was no significant difference in age or BMI between the two groups, however, fasting blood glucose, hemoglobin A1c, triglyceride, cholesterol levels, the prevalence of abnormal glucose tolerance, hypercholesterolemia, fatty liver (30.5% vs. 15.7%, p < 0.01), and morbidity index for CHD risk factors (sum of the five risk factors scored as one point each if present) (1.46 vs. 1.04, p < 0.01) were significantly higher in the high waist/height group. In conclusion, even normal BMI subjects should pay attention to their waist/height ratio because of higher CHD risk factor levels, prevalences, morbidity index for CHD risk factors, and higher prevalence of fatty liver.

摘要

在接受常规健康检查的中年男性(45 - 54岁,体重指数:22 - 23.2 kg/m²)中,对正常体重指数(BMI)且腰高比高或低的受试者的冠心病(CHD)危险因素水平进行了调查,这些危险因素包括收缩压和舒张压、空腹血糖、糖化血红蛋白、甘油三酯、胆固醇、高密度脂蛋白胆固醇、高血压患病率、糖耐量异常、高甘油三酯血症、高胆固醇血症、低高密度脂蛋白胆固醇水平和脂肪肝。根据腰高比是否≥0.5(n = 131)或<0.5(n = 121)将受试者分为两组。两组之间的年龄或BMI无显著差异,然而,高腰高比组的空腹血糖、糖化血红蛋白、甘油三酯、胆固醇水平、糖耐量异常患病率、高胆固醇血症、脂肪肝患病率(30.5%对15.7%,p<0.01)以及冠心病危险因素发病指数(五个危险因素每项存在计一分的总和)(1.46对1.04,p<0.01)显著更高。总之,即使是正常BMI的受试者也应关注其腰高比,因为冠心病危险因素水平、患病率、冠心病危险因素发病指数以及脂肪肝患病率更高。

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