Van Steenbergen W
Afdeling Hepatologie, Universitair Ziekenhuis Gasthuisberg, Leuven.
Tijdschr Gerontol Geriatr. 1996 Oct;27(5):191-6.
Normal pancreatic ageing is characterized by functional and morphological changes of the pancreatic parenchyma and of the ductal system, which, however, do not interfere with normal exocrine pancreatic function. It can be speculated that 'pancreatic lithiasis in the aged' as well as the 'senile idiopathic chronic pancreatitis', two conditions of chronic pancreatitis in the elderly, may represent more extreme forms of these normal age-related changes in pancreatic structure and function. In elderly people, acute and chronic pancreatitis are only rarely related to alcohol abuse, in contrast to the situation in a younger patient population. The presence of gallstones represents the most frequent cause of acute pancreatitis in the elderly. In most aged patients with acute biliary pancreatitis, endoscopic sphincterotomy is the treatment of choice, even when bile duct stones cannot clearly be demonstrated at ERCP. Endoscopic sphincterotomy has been shown to reduce morbidity as well as mortality rates in acute biliary pancreatitis. This technique can even be considered as treatment of choice in elderly patients with an increased operative risk. An elective laparoscopic cholecystectomy should be performed in elderly patients with an acceptable operative risk.
正常胰腺老化的特征是胰腺实质和导管系统的功能及形态变化,不过这些变化并不影响胰腺正常的外分泌功能。可以推测,“老年胰腺结石”以及“老年特发性慢性胰腺炎”这两种老年人慢性胰腺炎的情况,可能代表了胰腺结构和功能这些正常的年龄相关变化的更极端形式。与年轻患者群体的情况不同,老年人的急性和慢性胰腺炎很少与酒精滥用有关。胆结石的存在是老年人急性胰腺炎最常见的病因。在大多数老年急性胆源性胰腺炎患者中,即使在ERCP检查中不能明确显示胆管结石,内镜括约肌切开术也是首选的治疗方法。内镜括约肌切开术已被证明可降低急性胆源性胰腺炎的发病率和死亡率。对于手术风险增加的老年患者,甚至可以将这种技术视为首选治疗方法。对于手术风险可接受的老年患者,应进行择期腹腔镜胆囊切除术。