[苯乙烯暴露风险工人自由基活性的测定]
[Determination of free radical activity in workers at risk for styrene exposure].
作者信息
Kohout J, Holecek V, Machartová V, Racek J, Jerábek Z, Senft V
机构信息
Klinika pracovního lékarstvi, FN Plzen.
出版信息
Vnitr Lek. 1996 Aug;42(8):537-9.
The authors examined indicators of the effect of free radicals (MDA, SOD, GSHPx, selenium) in 38 workers exposed to styrene. They revealed a statistically significant (p < 0.01) correlation of SOD activity and the period of exposure to styrene and also a statistically significant correlation (p < 0.05) between urinary selenium excretion and the period of exposure to styrene as well as a statistically significant correlation (p < 0.01) between the MDA serum concentration and urinary selenium excretion. There is no statistically significant difference between the MDA plasma concentration among smokers and non-smokers, the SOD activity is significantly higher in non-smokers (p < 0.05). Based on the revealed findings the authors assume that free radicals may also play a part in the action of styrene on the organism.
作者检测了38名接触苯乙烯工人体内自由基（丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶、硒）作用的指标。他们发现超氧化物歧化酶活性与苯乙烯接触时间之间存在统计学显著相关性（p < 0.01），尿硒排泄量与苯乙烯接触时间之间也存在统计学显著相关性（p < 0.05），丙二醛血清浓度与尿硒排泄量之间同样存在统计学显著相关性（p < 0.01）。吸烟者与非吸烟者的丙二醛血浆浓度无统计学显著差异，非吸烟者的超氧化物歧化酶活性显著更高（p < 0.05）。基于这些发现，作者推测自由基可能也参与了苯乙烯对机体的作用。
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