Zółtowska K, Kurowicka B
Katedra Biologii Ogólnej WSP, Olsztyn.
Wiad Parazytol. 1996;42(2):205-12.
The development of Ascaris suum eggs maintained in the culture containing moxidectin (Cydectin, Cyanamid) in concentration 1, 5, 25, and 50 micrograms/ml was studied. The abnormalities and slowing down of the rate of eggs development, depending on the drug concentration, were observed. Exposure of eggs to moxidectin in concentration 1 and 5 microgram/ml resulted in one- or two-week delay of development. In the higher concentration of moxidectin (25 micrograms/ml) only 18% of eggs became invasive. In the presence of 50 micrograms/ml of the drug only few eggs developed to invasive stage after 7 weeks. The development of embryons was stopped more often in the blastula or gastrula stage. The drug's solvent in the highest concentration restricted the development of Ascaris eggs by about 10%. Unembryonated eggs of the worm appeared to be unaffected by 50 micrograms/ml of moxidectin treatment lasting 1-4 days, but for slowing down a little the development rate. The same concentration of the drug in the culture during the first four days of development resulted in 20% reduction of invasive stage in comparison to the control.
研究了猪蛔虫卵在含有浓度为1、5、25和50微克/毫升莫西菌素（赛得菌素，氰胺公司）的培养基中的发育情况。观察到根据药物浓度不同，虫卵发育速率出现异常和减缓。将虫卵暴露于浓度为1和5微克/毫升的莫西菌素中会导致发育延迟一到两周。在较高浓度的莫西菌素（25微克/毫升）下，只有18%的虫卵具有侵袭性。在存在50微克/毫升药物的情况下，7周后只有少数虫卵发育到侵袭阶段。胚胎发育更常停滞在囊胚或原肠胚阶段。最高浓度的药物溶剂使猪蛔虫卵的发育受到约10%的限制。未受精的虫卵似乎不受持续1 - 4天的50微克/毫升莫西菌素处理的影响，但发育速率略有减缓。在发育的前四天，培养基中相同浓度的药物与对照组相比，侵袭阶段减少了20%。
