Paolisso G, Gambardella A, Ammendola S, D'Amore A, Balbi V, Varricchio M, D'Onofrio F
Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.
Am J Physiol. 1996 May;270(5 Pt 1):E890-4. doi: 10.1152/ajpendo.1996.270.5.E890.
Advancing age has been found to be associated with a decline in insulin action. Nevertheless, no study has been conducted in healthy centenarians. Our study investigates glucose tolerance and insulin action in centenarians. Fifty-two subjects were enrolled. The subjects were divided in three groups as follows: 1) adults (< 50 yr; n = 20);2) aged subjects (> 75 yr; n = 22); and 3) centenarians (> 100 yr; n = 14). Body composition was studied by bioimpedance analysis. In all subjects, an oral glucose tolerance test and euglycemic glucose clamp were performed. Centenarians have a lower fat-free mass (FFM) than aged subjects and adults, whereas fasting plasma glucose, triglycerides, free fatty acids, urea, and creatinine were not different in the groups studies. Centenarians had a 2-h plasma glucose concentration (6.0 +/- 0.2 mmol/l) that was lower than that in aged subjects (6.6 +/- 0.5 mmol/l, P < 0.05) but not different from adults [6.4 +/- 0.4 mmol/l, P = not significant (NS)]. During the clamp, plasma glucose and insulin concentrations were similar in the three groups. In these conditions, centenarians had a whole body glucose disposal (34.1 +/- 0.6 mumol.kg FFM-1.min 1) that was greater than that in aged subjects (23.3 +/- 0.5 mumol.kg FFM-1.min-1 P < 0.01) but not different from adults (34.6 +/- 0.5 mumol/kg x min, P = NS). In conclusion, our study demonstrates that centenarians compared with aged subjects had a preserved glucose tolerance and insulin action.
研究发现，增龄与胰岛素作用下降有关。然而，尚未对健康的百岁老人进行过相关研究。我们的研究调查了百岁老人的葡萄糖耐量和胰岛素作用。共招募了52名受试者。受试者被分为以下三组：1）成年人（<50岁；n = 20）；2）老年受试者（>75岁；n = 22）；3）百岁老人（>100岁；n = 14）。通过生物电阻抗分析研究身体成分。对所有受试者进行了口服葡萄糖耐量试验和正常血糖葡萄糖钳夹试验。百岁老人的去脂体重（FFM）低于老年受试者和成年人，而在各研究组中，空腹血糖、甘油三酯、游离脂肪酸、尿素和肌酐并无差异。百岁老人的2小时血浆葡萄糖浓度（6.0±0.2 mmol/l）低于老年受试者（6.6±0.5 mmol/l，P<0.05），但与成年人无差异[6.4±0.4 mmol/l，P = 无显著性差异（NS）]。在钳夹试验期间，三组的血浆葡萄糖和胰岛素浓度相似。在这些情况下，百岁老人的全身葡萄糖处置率（34.1±0.6 μmol·kg FFM-1·min-1）高于老年受试者（23.3±0.5 μmol·kg FFM-1·min-1，P<0.01），但与成年人无差异（34.6±0.5 μmol/kg·min，P = NS）。总之，我们的研究表明，与老年受试者相比，百岁老人具有保留的葡萄糖耐量和胰岛素作用。
