Unit of epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177, Stockholm, Sweden.
Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Geroscience. 2024 Apr;46(2):1693-1702. doi: 10.1007/s11357-023-00936-w. Epub 2023 Sep 19.
Comparing biomarker profiles measured at similar ages, but earlier in life, among exceptionally long-lived individuals and their shorter-lived peers can improve our understanding of aging processes. This study aimed to (i) describe and compare biomarker profiles at similar ages between 64 and 99 among individuals eventually becoming centenarians and their shorter-lived peers, (ii) investigate the association between specific biomarker values and the chance of reaching age 100, and (iii) examine to what extent centenarians have homogenous biomarker profiles earlier in life. Participants in the population-based AMORIS cohort with information on blood-based biomarkers measured during 1985-1996 were followed in Swedish register data for up to 35 years. We examined biomarkers of metabolism, inflammation, liver, renal, anemia, and nutritional status using descriptive statistics, logistic regression, and cluster analysis. In total, 1224 participants (84.6% females) lived to their 100th birthday. Higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching 100 years. Centenarians overall displayed rather homogenous biomarker profiles. Already from age 65 and onwards, centenarians displayed more favorable biomarker values in commonly available biomarkers than individuals dying before age 100. The differences in biomarker values between centenarians and non-centenarians more than one decade prior death suggest that genetic and/or possibly modifiable lifestyle factors reflected in these biomarker levels may play an important role for exceptional longevity.
比较在相似年龄但生命早期的超长寿命个体和其寿命较短的同龄人之间测量的生物标志物谱，可以增进我们对衰老过程的理解。本研究旨在：(i) 描述并比较最终成为百岁老人及其寿命较短的同龄人在 64 至 99 岁时相似年龄的生物标志物谱；(ii) 研究特定生物标志物值与达到 100 岁年龄的几率之间的关联；(iii) 检验百岁老人在生命早期是否具有相似的生物标志物谱。在基于人群的 AMORIS 队列中，有在 1985-1996 年期间测量的基于血液的生物标志物信息的参与者，通过瑞典登记数据进行了长达 35 年的随访。我们使用描述性统计、逻辑回归和聚类分析来检查代谢、炎症、肝脏、肾脏、贫血和营养状况的生物标志物。共有 1224 名参与者（84.6%为女性）活到 100 岁。总胆固醇和铁水平较高，葡萄糖、肌酐、尿酸、天冬氨酸转氨酶、γ-谷氨酰转移酶、碱性磷酸酶、乳酸脱氢酶和总铁结合能力较低与达到 100 岁有关。总体而言，百岁老人的生物标志物谱相当相似。从 65 岁开始，百岁老人的常用生物标志物值就比 100 岁前死亡的个体更有利。在死亡前超过 10 年的百岁老人和非百岁老人之间的生物标志物值差异表明，这些生物标志物水平所反映的遗传和/或可能可改变的生活方式因素可能对超长寿命起着重要作用。
