与快速眼动睡眠行为障碍相关的人类白细胞抗原II类基因。

HLA class II genes associated with REM sleep behavior disorder.

作者信息

Schenck C H, Garcia-Rill E, Segall M, Noreen H, Mahowald M W

机构信息

Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, Minneapolis, MN 55415, USA.

出版信息

Ann Neurol. 1996 Feb;39(2):261-3. doi: 10.1002/ana.410390216.

DOI:10.1002/ana.410390216

PMID:8967758

Abstract

Twenty-five white men with rapid eye movements (REM) sleep behavior disorder, but without narcolepsy, underwent HLA class II antigen typing: 84% (N=21) were DQwl (DQB105,06) positive (28% [N=7] were DR2 positive); DQB10501 (N=9) and DQB1*0602 (N=7) were the most common phenotypes. The 84% DQwl rate in men with REM sleep behavior disorder was significantly greater (p=0.015) than the 56% DQwl rate found in a local white comparison group (N=66), and was greater than the 39 to 66% DQwl rates published for 12 white groups (N=40-418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class II genes.

摘要

25名患有快速眼动（REM）睡眠行为障碍但无发作性睡病的白人男性接受了HLA II类抗原分型：84%（N = 21）为DQwl（DQB105,06）阳性（28% [N = 7]为DR2阳性）；DQB10501（N = 9）和DQB1*0602（N = 7）是最常见的表型。患有REM睡眠行为障碍的男性中84%的DQwl率显著高于本地白人对照组（N = 66）中56%的DQwl率（p = 0.015），且高于已发表的12个白人组（每组N = 40 - 418）中39%至66%的DQwl率。因此，另一种REM睡眠调节障碍（除发作性睡病外）似乎与特定的HLA II类基因密切相关。