Grayson J K, Lyons T J
Armstrong Laboratory, Aerospace Medicine Directorate, Brooks AFB, TX 78235-5241, USA.
Aviat Space Environ Med. 1996 Dec;67(12):1152-4.
We compared the brain cancer risk of male United States Air Force (USAF) aircrew (37 cases) with nonflying Air Force personnel (193 cases) between 1970 and 1989.
Incident brain cancer cases for both aviators and nonflying USAF personnel were obtained from USAF hospitalization records. Age, race, and calendar time matched controls were randomly selected for each case from the remaining USAF cohort. We estimated brain cancer risks using conditional logistic regression models.
Initially, we observed a statistically significant brain cancer excess for USAF aircrew compared to nonflying USAF personnel (Odds Ratio [OR] = 1.77, 95% Confidence interval [95% CI] 1.17-2.68). However, following adjustment for senior military rank, a socioeconomic status indicator, the USAF aircrew brain cancer risk was markedly reduced (OR = 1.22, 95% CI 0.76-1.95), demonstrating that much of the previously observed USAF aircrew brain cancer risk was attributable to factors other than flying.
The results of this investigation indicate that flying is not an important brain cancer risk factor, at least for USAF aircrew. The positive relationships observed in other studies between commercial aircrew and brain cancer risk may have been confounded by social class differentials.
我们比较了1970年至1989年间美国空军男性机组人员（37例）与非飞行空军人员（193例）患脑癌的风险。
飞行员和非飞行美国空军人员的脑癌发病病例均来自美国空军住院记录。从其余美国空军队列中为每个病例随机选取年龄、种族和日历时间匹配的对照。我们使用条件逻辑回归模型估计脑癌风险。
最初，我们观察到与非飞行美国空军人员相比，美国空军机组人员患脑癌的比例有统计学显著增加（优势比[OR]=1.77，95%置信区间[95%CI]1.17 - 2.68）。然而，在对作为社会经济地位指标的高级军衔进行调整后，美国空军机组人员患脑癌的风险显著降低（OR = 1.22，95%CI 0.76 - 1.95），这表明之前观察到的美国空军机组人员患脑癌风险的很大一部分可归因于飞行以外的因素。
这项调查结果表明，至少对于美国空军机组人员而言，飞行并非患脑癌的重要风险因素。其他研究中观察到的商业机组人员与脑癌风险之间的正相关关系可能受到社会阶层差异的混淆。
