Rosenblatt K A, Thomas D B
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Contraception. 1996 Dec;54(6):329-32. doi: 10.1016/s0010-7824(96)00199-0.
The relationship between intrauterine device (IUD) use and the development of endometrial cancer was assessed in data from seven countries that were collected between 1979 and 1988 for a multinational hospital-based case-control study. Two hundred twenty-six cases of endometrial cancer were compared with 1,529 controls matched for age, hospital, and year of interview. No significant association between use of an IUD and risk of endometrial cancer was observed (OR = 0.74, 95% CI = 0.4-1.33). There were no trends in risk with respect to duration of use, time since first use, or ages at first or last use. No cases had used a copper IUD (OR = 0, 95% CI = 0-1.71). Although women over age 55 who had used an IUD were at significantly increased risk, this unexpected finding is based on small numbers of users and requires independent confirmation. These results, along with those from other studies, provide reassurance that risk of endometrial cancer is unlikely to be increased by use of an IUD.
在1979年至1988年期间为一项跨国医院病例对照研究收集的来自七个国家的数据中，评估了宫内节育器（IUD）的使用与子宫内膜癌发生之间的关系。将226例子宫内膜癌病例与1529例在年龄、医院和访谈年份方面相匹配的对照进行了比较。未观察到使用IUD与子宫内膜癌风险之间存在显著关联（比值比=0.74，95%置信区间=0.4-1.33）。在使用持续时间、首次使用以来的时间或首次或末次使用时的年龄方面，风险没有趋势。没有病例使用过铜质IUD（比值比=0，95%置信区间=0-1.71）。尽管使用过IUD的55岁以上女性风险显著增加，但这一意外发现基于少量使用者，需要独立证实。这些结果与其他研究的结果一起，让人放心使用IUD不太可能增加子宫内膜癌的风险。
