Lassise D L, Savitz D A, Hamman R F, Barón A E, Brinton L A, Levines R S
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver.
Int J Epidemiol. 1991 Dec;20(4):865-70. doi: 10.1093/ije/20.4.865.
Although the hypothesis that intrauterine device (IUD) use might promote cervical cancer has been considered since the introduction of IUDs in the early 1900s, previous studies are inconclusive. Data collected in interviews with 481 invasive cervical cancer cases and 801 general population controls from Birmingham, Chicago, Denver, Miami and Philadelphia were used to address this issue. These data were analysed to determine the relationship between IUD use and the risk of cervical cancer, with consideration of the type of IUD (copper and inert) and duration of use. A non-significant reduced risk of cervical cancer was associated with copper IUD use, indicated by an adjusted odds ratio (OR) of 0.6 (95% Cl: 0.3-1.2), but virtually no effect was found for inert IUD use (OR = 1.1, 95% Cl: 0.9-1.7). Decreased risk with increased duration of copper IUD use supports a possible protective effect of copper IUD use on the development of invasive cervical cancer.
自20世纪初宫内节育器（IUD）问世以来，关于使用IUD可能会引发宫颈癌的假说就一直受到关注，但此前的研究尚无定论。本研究采用对来自伯明翰、芝加哥、丹佛、迈阿密和费城的481例浸润性宫颈癌病例以及801例普通人群对照进行访谈所收集的数据，来探讨这一问题。对这些数据进行分析，以确定使用IUD与患宫颈癌风险之间的关系，并考虑了IUD的类型（铜质和惰性）以及使用时长。使用铜质IUD与宫颈癌风险降低无显著关联，校正优势比（OR）为0.6（95%可信区间：0.3 - 1.2），而使用惰性IUD则几乎没有影响（OR = 1.1，95%可信区间：0.9 - 1.7）。随着铜质IUD使用时长增加风险降低，这支持了使用铜质IUD对浸润性宫颈癌发生可能具有保护作用的观点。
