体脂堆积可能是绝经前肥胖女性循环中脱氢表雄酮水平较低的原因。
Body fat accumulation is possibly responsible for lower dehydroepiandrosterone circulating levels in premenopausal obese women.
作者信息
De Pergola G, Zamboni M, Sciaraffia M, Turcato E, Pannacciulli N, Armellini F, Giorgino F, Perrini S, Bosello O, Giorgino R
机构信息
Institute of Medical Clinic, Endocrinology and Metabolic Diseases, School of Medicine, University of Bari, Policlinco di Bari, Italy.
出版信息
Int J Obes Relat Metab Disord. 1996 Dec;20(12):1105-10.
OBJECTIVE
To determine whether any androgen is independently related with parameters of body fat accumulation and distribution in obese women.
DESIGN
Circulating insulin and androgen levels (total testosterone (T), free testosterone (FT), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione, sex hormone binding globulin (SHBG)) and the parameters of body fat accumulation and distribution (body mass index, waist-to-hip ratio, total body fat volume (TBF), visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were determined in a population of non-diabetic obese women.
SUBJECTS
28 premenopausal obese women, recruited at the Verona University Hospital Outpatient Clinic.
MEASUREMENTS
TBF, VAT and SAT area were quantified by computed tomography. Hormone levels were measured by RIA.
RESULTS
SHBG showed an inverse correlation with BMI (r: -0.452, P < 0.05), WHR (r: -0.388, P < 0.05), TBF (r: -0.509, P < 0.01), VAT (r: -0.378, P < 0.05) and SAT (r: -0.449, P < 0.05). DHEA was negatively associated with BMI (r: -0.376, P < 0.05), TBF (r: -0 < 0.05), VAT (r: -0.662, P < 0.001) and SAT (r: -0.401, p < 0.05). T was found to be inversely related with VAT (r: -0.401, P < 0.05). Androstenedione was positively correlated with WHR (r: 0.383, P < 0.05). DHEAS and FT did not show significant associations with BMI, WHR, or any CT-parameters. Stepwise multiple regressions were performed for all androgens: one of the age-adjusted androgens was considered as the dependent variable for each analysis, and insulin, VAT, SAT and all other androgens were entered into the regression model. DHEA was the only hormone to show an independent association (negative) with both SAT (t-value: -3.683, P < 0.01) and VAT (t-value: -2.252, P < 0.05), whereas DHEAS showed an independent positive correlation with SAT (t-value: -2.241, P < 0.05).
CONCLUSIONS
Among the androgens, DHEA seems to be the most sensitive to body fat accumulation in premenopausal obese women.
目的
确定是否有任何雄激素与肥胖女性体内脂肪堆积和分布的参数独立相关。
设计
在一组非糖尿病肥胖女性中，测定循环胰岛素和雄激素水平（总睾酮（T）、游离睾酮（FT）、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEAS）、雄烯二酮、性激素结合球蛋白（SHBG））以及体内脂肪堆积和分布的参数（体重指数、腰臀比、总体脂量（TBF）、内脏脂肪组织面积（VAT）和皮下脂肪组织面积（SAT））。
研究对象
28名绝经前肥胖女性，招募于维罗纳大学医院门诊。
测量方法
通过计算机断层扫描对TBF、VAT和SAT面积进行定量。激素水平通过放射免疫分析法测定。
结果
SHBG与BMI（r：-0.452，P<0.05）、WHR（r：-0.388，P<0.05）、TBF（r：-0.509，P<0.01）、VAT（r：-0.378，P<0.05）和SAT（r：-0.449，P<0.05）呈负相关。DHEA与BMI（r：-0.376，P<0.05）、TBF（r：-0<0.05）、VAT（r：-0.662，P<0.001）和SAT（r：-0.401，P<0.05）呈负相关。发现T与VAT呈负相关（r：-0.401，P<0.05）。雄烯二酮与WHR呈正相关（r：0.383，P<0.05）。DHEAS和FT与BMI、WHR或任何CT参数均无显著关联。对所有雄激素进行逐步多元回归分析：每次分析将一种年龄校正后的雄激素作为因变量，胰岛素、VAT、SAT和所有其他雄激素纳入回归模型。DHEA是唯一与SAT（t值：-3.683，P<0.01）和VAT（t值：-2.252，P<0.）均显示独立关联（负相关）的激素，而DHEAS与SAT呈独立正相关（t值：-2.241，P<0.05）。
结论
在雄激素中，DHEA似乎是绝经前肥胖女性体内脂肪堆积最敏感的指标。
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