Sezione di Endocrinologia, Dipartimento di Medicina Clinica e Chirurgia, Università Federico II di Napoli, Via S. Pansini 5-80131 Naples, Italy.
J Endocrinol Invest. 2013 Apr;36(4):267-79. doi: 10.3275/8880. Epub 2013 Feb 27.
Bariatric surgery is nowadays an effective therapeutic option for morbid obesity. Endocrinologists may thus have a growing opportunity to diagnose and treat obese patients eligible for surgery in pre- and post-operative phase. This requires a better understanding of endocrine changes caused by either obesity or weight loss surgery. Despite the large number of studies available in literature, only limited well-designed clinical trials have been performed so far to investigate changes of endocrine axes following bariatric procedures. There are still areas of unclear results such as female and male fertility, however, weight loss after bariatric surgery is considered to be associated with favorable effects on most endocrine axes. The aim of this clinical review is to overview the available literature on the effects of weight loss after bariatric surgery on the endocrine systems to suggest the most appropriate pre- and post-operative management of obese patients undergoing bariatric surgery in terms of "endocrine" health.
如今，减重手术是治疗病态肥胖的有效治疗选择。因此，内分泌学家可能有越来越多的机会在肥胖患者的手术前后阶段诊断和治疗符合手术条件的肥胖患者。这需要更好地了解肥胖或减重手术引起的内分泌变化。尽管文献中有大量的研究，但到目前为止，只有有限的精心设计的临床试验来研究减重手术后内分泌轴的变化。仍有一些领域的结果不明确，如女性和男性的生育能力，然而，减重手术可以降低肥胖患者的体脂率，被认为对大多数内分泌轴都有有利影响。本临床综述的目的是概述减重手术后体重减轻对内分泌系统的影响，以就肥胖患者接受减重手术时的“内分泌”健康问题提出最合适的术前和术后管理建议。
