Rissanen J, Hudson R, Ross R
School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada.
Metabolism. 1994 Oct;43(10):1318-23. doi: 10.1016/0026-0495(94)90229-1.
The primary purpose of this study was to investigate the relationships between adipose tissue (AT) distribution, particularly visceral adipose tissue (VAT), circulating androgens, and plasma lipids in a group of 17 obese (body mass index [kg/m2], 31.8 +/- 3.8) android (waist to hip ratio [WHR], 1.01 +/- 0.05) men. AT distribution was measured by magnetic resonance imaging (MRI) using a multislice model in which 41 equidistant images were acquired from head to foot. Although the subjects were homogenous with respect to total adiposity, a sevenfold variation in VAT was observed. VAT and the visceral to subcutaneous ratio (VSR) were significantly correlated with triglyceride (TG) levels and the ratio of apolipoprotein (apo) B to low-density lipoprotein cholesterol ([LDL-C] P < .05). Neither proximal-thigh AT area nor lower-body subcutaneous adipose tissue (SAT) volume was significantly related to any lipid variable. However, the ratio of visceral AT area to thigh AT area (VTH) was positively correlated with TG (P < .05), and the ratio of VAT volume to lower-body SAT volume (VLBS) was positively correlated with TG, total cholesterol (TC), LDL-C (P < .05), and apo B (P = .057). Total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) were not significantly related to any of the plasma lipid variables; however, the percentage of FT (%FT) was positively correlated with high-density lipoprotein cholesterol ([HDL-C]P < .01) and HDL-C/LDL-C (P < .05). TT, FT, %FT, and SHBG were not related to MRI-measured VAT. Age waa not related to either VAT or androgen levels.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的主要目的是调查一组17名肥胖（体重指数[kg/m²]，31.8±3.8）男性的脂肪组织（AT）分布，尤其是内脏脂肪组织（VAT）、循环雄激素和血浆脂质之间的关系。这些男性具有男性化体型（腰臀比[WHR]，1.01±0.05）。使用多层模型通过磁共振成像（MRI）测量AT分布，该模型从头部到脚部采集41张等距图像。尽管受试者在总脂肪量方面具有同质性，但观察到VAT存在7倍的差异。VAT和内脏与皮下脂肪比例（VSR）与甘油三酯（TG）水平以及载脂蛋白（apo）B与低密度脂蛋白胆固醇（[LDL-C]P<0.05）的比例显著相关。大腿近端AT面积和下半身皮下脂肪组织（SAT）体积均与任何脂质变量无显著相关性。然而，内脏AT面积与大腿AT面积的比例（VTH）与TG呈正相关（P<0.05），VAT体积与下半身SAT体积的比例（VLBS）与TG、总胆固醇（TC）、LDL-C（P<0.05）和apo B（P=0.057）呈正相关。总睾酮（TT）、游离睾酮（FT）和性激素结合球蛋白（SHBG）与任何血浆脂质变量均无显著相关性；然而，游离睾酮百分比（%FT）与高密度脂蛋白胆固醇（[HDL-C]P<0.01）和HDL-C/LDL-C（P<0.05）呈正相关。TT、FT、%FT和SHBG与MRI测量的VAT无关。年龄与VAT或雄激素水平均无关。（摘要截断于250字）
