Takeda N, Horii A, Uno A, Morita M, Mochizuki T, Yamatodani A, Kubo T
Department of Otolaryngology, Faculty of Medicine, Osaka University, Japan.
J Vestib Res. 1996 Nov-Dec;6(6):403-9.
We examined the effect and aftereffect of acute or chronic load of hypergravity produced by an animal centrifuge, on pica (that is, kaolin intake) in the rat as an index of motion sickness. Although the degree of pica initially induced by acute or chronic hypergravity was not different, the rate of decline of increased kaolin intake over poststimulus days was different. Pica after a 1-h load of 2g decreased rapidly. On the other hand, pica lasted 3 days after a 48-h load of 2g. These findings suggest that the aftereffects of chronic hypergravity application on pica are due to motion sickness induced by readaptation to normal gravity, and they support our idea that after adaptation to a hypergravity environment, return and readaptation to the normal gravity can simulate exposure and adaptation to microgravity. We concluded that motion sickness in rats induced by the aftereffects of chronic hypergravity stimulation can be used as a ground-based animal model of space adaptation syndrome.
我们研究了动物离心机产生的急性或慢性超重力负荷对大鼠异食癖（即高岭土摄入量）的影响及后效应，以此作为晕动病的指标。尽管急性或慢性超重力最初诱发的异食癖程度并无差异，但刺激后数天内高岭土摄入量增加的下降速率有所不同。2g负荷1小时后异食癖迅速下降。另一方面，2g负荷48小时后异食癖持续3天。这些发现表明，慢性超重力作用对异食癖的后效应是由于重新适应正常重力诱发的晕动病，并且支持了我们的观点，即适应超重力环境后，返回并重新适应正常重力可模拟暴露于微重力及适应微重力的过程。我们得出结论，慢性超重力刺激后效应诱发的大鼠晕动病可作为空间适应综合征的地面动物模型。
