Casner P R
Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso 79905, USA.
South Med J. 1996 Dec;89(12):1200-3. doi: 10.1097/00007611-199612000-00014.
The warfarin-rifampin interaction is a well-described but underappreciated drug interaction. A case is reported in which therapeutic anticoagulation could not be achieved after nearly 4 weeks of warfarin therapy because of simultaneous administration of rifampin. This patient had the highest warfarin clearance ever reported in the literature. The world's literature describing warfarin-rifampin interactions for the past 32 years was reviewed to suggest guidelines for warfarin dosage when rifampin is given simultaneously.
华法林与利福平的相互作用是一种已被充分描述但未得到充分重视的药物相互作用。本文报告了一例患者，在华法林治疗近4周后，由于同时服用利福平，未能实现治疗性抗凝。该患者的华法林清除率是文献报道中最高的。回顾了过去32年描述华法林与利福平相互作用的世界文献，以提出同时给予利福平时华法林剂量的指导原则。
