Hu Ya-Ni, Zhou Bo-Ting, Yang Hua-Rong, Peng Qi-Lin, Gu Xu-Rui, Sun Shu-Sen
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
College of Pharmacy and Health Sciences, Western New England University, Springfield, MA 31329, United States.
World J Clin Cases. 2021 Feb 16;9(5):1087-1095. doi: 10.12998/wjcc.v9.i5.1087.
The drug interaction between warfarin and rifampicin is widely known, but there are still some difficulties in managing the combination of the two drugs.
A patient with brucellosis received strict monitoring from a Chinese pharmacist team during combination of warfarin and rifampicin. The dose of warfarin was increased to 350% in 3 mo before reaching the lower international normalized ratio treatment window. No obvious adverse reaction occurred during the drug-adjustment period. This is the first case report of long-term combined use of rifampicin and warfarin in patients with brucellosis and valve replacement in China based on the Chinese lower warfarin dose and international normalized ratio range.
Anticoagulation for valve replacement in Chinese patients differs from that in other races. Establishment of a pharmacist clinic provides vital assistance in warfarin dose adjustment.
华法林与利福平之间的药物相互作用广为人知，但在管理这两种药物的联合使用方面仍存在一些困难。
一名布鲁氏菌病患者在华法林与利福平联合使用期间接受了中国药师团队的严格监测。在达到较低国际标准化比值治疗窗之前的3个月内，华法林剂量增加至350%。在药物调整期间未发生明显不良反应。这是中国首例基于较低华法林剂量和国际标准化比值范围的布鲁氏菌病合并瓣膜置换患者长期联合使用利福平和华法林的病例报告。
中国患者瓣膜置换的抗凝治疗与其他种族不同。药师门诊的建立为华法林剂量调整提供了重要帮助。
