De Somer D, Foubert L, Vanackere M, Dujardin D, Delanghe J, Van Nooten G
Department of Perfusion, University Hospital Gent, Belgium.
J Cardiothorac Vasc Anesth. 1996 Dec;10(7):884-9. doi: 10.1016/s1053-0770(96)80050-4.
To determine whether relative pressure drop, shear stress, hemolysis, and white blood cell and platelet counts are influenced by different oxygenator designs. To compare the oxygenator results with the average shear stress over an arterial cannula.
Prospective; patients enrolled consecutively.
University hospital.
Three groups of 12 adults patients, scheduled for routine cardiac surgery.
Each group was submitted to a different oxygenator design: group 1 to a high-pressure hollow-fiber membrane oxygenator (Sarns Turbo); group 2 to a medium-pressure hollow-fiber membrane oxygenator (Cobe optima); and group 3 to a flat-sheet membrane oxygenator (Cobe Duo).
Although the investigated oxygenators have important differences in pressure drop and shear stress, no statistical differences were found in hemolysis generation or blood handling among the different groups. Actually, the study shows much higher shear stress levels over an average arterial cannula than over any of the evaluated oxygenators.
The pressure drop over an oxygenator does not correlate well with shear stress and hemolysis because the dimensions of the system (radius and length) must be included in the calculation of shear stress from pressure drop.
确定相对压力降、剪切应力、溶血以及白细胞和血小板计数是否受不同氧合器设计的影响。将氧合器的结果与动脉插管上的平均剪切应力进行比较。
前瞻性研究；连续纳入患者。
大学医院。
三组，每组12例计划进行常规心脏手术的成年患者。
每组使用不同设计的氧合器：第1组使用高压中空纤维膜氧合器（Sarns Turbo）；第2组使用中压中空纤维膜氧合器（Cobe optima）；第3组使用平板膜氧合器（Cobe Duo）。
尽管所研究的氧合器在压力降和剪切应力方面存在重要差异，但不同组之间在溶血产生或血液处理方面未发现统计学差异。实际上，该研究表明，平均动脉插管上的剪切应力水平远高于任何一种评估的氧合器。
氧合器上的压力降与剪切应力和溶血的相关性不佳，因为在根据压力降计算剪切应力时必须考虑系统的尺寸（半径和长度）。
