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用于诊断囊性纤维化的汗液检测:实际考量

Sweat testing for the diagnosis of cystic fibrosis: practical considerations.

作者信息

LeGrys V A

机构信息

Division of Clinical Laboratory Science, University of North Carolina, Chapel Hill School of Medicine 27599-7145, USA.

出版信息

J Pediatr. 1996 Dec;129(6):892-7. doi: 10.1016/s0022-3476(96)70034-3.

DOI:10.1016/s0022-3476(96)70034-3
PMID:8969732
Abstract

Most pediatricians eventually encounter a patient with a clinical presentation that warrants the consideration of a sweat test to rule out of confirm the diagnosis of cystic fibrosis. This article discusses, in a series of questions and answers, the currently available sweat testing methods and describes the various methods' reliability, limitations, and frequency of use. In addition, sweat testing utilization and the interpretation and evaluation of test results are discussed so that the clinician can critically analyze the laboratory data.

摘要

大多数儿科医生最终都会遇到这样一位患者,其临床表现需要考虑进行汗液测试以排除或确诊囊性纤维化。本文通过一系列问答讨论了目前可用的汗液测试方法,并描述了各种方法的可靠性、局限性和使用频率。此外,还讨论了汗液测试的应用以及测试结果的解读和评估,以便临床医生能够严格分析实验室数据。

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1
Sweat testing for the diagnosis of cystic fibrosis: practical considerations.用于诊断囊性纤维化的汗液检测:实际考量
J Pediatr. 1996 Dec;129(6):892-7. doi: 10.1016/s0022-3476(96)70034-3.
2
Delayed diagnosis of cystic fibrosis due to normal sweat electrolytes.因汗液电解质正常导致的囊性纤维化延迟诊断。
J R Soc Med. 1995 Jul;88(7):417P-418P.
3
Reliability of sweat test in cystic fibrosis.囊性纤维化中汗液测试的可靠性。
J Pediatr. 1979 Oct;95(4):661-2. doi: 10.1016/s0022-3476(79)80794-5.
4
Clinical evaluation of the macroduct sweat collection system and conductivity analyzer in the diagnosis of cystic fibrosis.大导管汗液收集系统和电导率分析仪在囊性纤维化诊断中的临床评估
J Pediatr. 1994 Feb;124(2):255-60. doi: 10.1016/s0022-3476(94)70314-0.
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Sweat testing: can the conductivity analysis take the place of the classic Gibson and Cooke technique?汗液检测:传导性分析能否取代经典的吉布森和库克技术?
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[Value of sweat conductivity testing in the diagnosis of cystic fibrosis in children].[汗液传导性检测在儿童囊性纤维化诊断中的价值]
Zhonghua Er Ke Za Zhi. 2019 Jul 2;57(7):548-552. doi: 10.3760/cma.j.issn.0578-1310.2019.07.011.
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[Sweat testing practices in German cystic fibrosis centres].[德国囊性纤维化中心的汗液检测实践]
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Reliability of sweat tests in diagnosis of cystic fibrosis.
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Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects.3834名受试者汗液电导率和氯化物滴定法用于囊性纤维化诊断
J Cyst Fibros. 2003 Mar;2(1):1-7. doi: 10.1016/S1569-1993(02)00146-7.
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Indirect measurements of sweat electrolyte concentration in the laboratory diagnosis of cystic fibrosis.实验室诊断囊性纤维化时汗液电解质浓度的间接测量
Arch Dis Child. 2000 May;82(5):420-4. doi: 10.1136/adc.82.5.420.

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Comparison between Gibson-Cooke and Macroduct Methods in the Cystic Fibrosis Neonatal Screening Program and in Subjects Who Are Cystic Fibrosis Screen-Positive with an Inconclusive Diagnosis.吉布森-库克法与宏导管法在囊性纤维化新生儿筛查项目及诊断不明确的囊性纤维化筛查阳性受试者中的比较。
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Scalable production of high-performing woven lithium-ion fibre batteries.可扩展生产高性能编织锂离子纤维电池。
Nature. 2021 Sep;597(7874):57-63. doi: 10.1038/s41586-021-03772-0. Epub 2021 Sep 1.
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Geographic distribution of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in Saudi Arabia.
沙特阿拉伯囊性纤维化跨膜传导调节因子(CFTR)基因突变的地理分布。
Int J Pediatr Adolesc Med. 2021 Mar;8(1):25-28. doi: 10.1016/j.ijpam.2019.12.002. Epub 2019 Dec 10.
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Sweat chloride quantification using capillary electrophoresis.使用毛细管电泳法定量汗液氯化物。
Pract Lab Med. 2018 Dec 7;13:e00114. doi: 10.1016/j.plabm.2018.e00114. eCollection 2019 Jan.
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Performance Evaluation of a New Coulometric Endpoint Method in Sweat Testing and Its Comparison With Classic Gibson&Cooke and Chloridometer Methods in Cystic Fibrosis.一种新型库仑滴定终点法在汗液检测中的性能评估及其与囊性纤维化经典吉布森和库克法及氯度计法的比较
Front Pediatr. 2018 May 22;6:133. doi: 10.3389/fped.2018.00133. eCollection 2018.
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Assessment of Correlation between Sweat Chloride Levels and Clinical Features of Cystic Fibrosis Patients.囊性纤维化患者汗液氯化物水平与临床特征的相关性评估。
J Clin Diagn Res. 2016 Dec;10(12):BC01-BC06. doi: 10.7860/JCDR/2016/21526.8951. Epub 2016 Dec 1.
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Recent developments in sweat analysis and its applications.汗液分析及其应用的最新进展。
Int J Anal Chem. 2015;2015:164974. doi: 10.1155/2015/164974. Epub 2015 Mar 9.
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Next generation sequencing to determine the cystic fibrosis mutation spectrum in Palestinian population.利用下一代测序技术确定巴勒斯坦人群中的囊性纤维化突变谱。
Dis Markers. 2015;2015:458653. doi: 10.1155/2015/458653. Epub 2015 Jan 26.
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Pulsed direct and constant direct currents in the pilocarpine iontophoresis sweat chloride test.匹鲁卡品电离子透入法汗氯试验中的脉冲直流电和恒直流电。
BMC Pulm Med. 2014 Dec 13;14:198. doi: 10.1186/1471-2466-14-198.
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Cystic fibrosis - the first interview.囊性纤维化——首次访谈。
Paediatr Child Health. 2001 Nov;6(9):620-2. doi: 10.1093/pch/6.9.620.