Geller N L, Proschan M
Office of Biostatistics Research, National Heart, Lung and Blood Institute, Rockledge Centre 2, Bethesda, Maryland 20892-7938, USA.
J Biopharm Stat. 1996 Nov;6(4):377-94. doi: 10.1080/10543409608835151.
Meta-analysis is a popular statistical tool allowing the synthesis of related research studies in a quantitative manner. Components of a good meta-analysis are first discussed, with a view toward critical reading of reports of meta-analyses. Examples include lipid-lowering drugs and coronary artery bypass graft surgery. A role for meta-analysis in the design and monitoring of clinical trials was examined at a workshop held at the National Institutes of Health and aspects of these uses of meta-analyses are considered. Basic analytical and graphical methods of meta-analysis are briefly reviewed. The goal is to encourage more thoughtful evaluation of the many meta-analyses that are published or are presented.
荟萃分析是一种常用的统计工具，它能够以定量的方式综合相关的研究。本文首先讨论了高质量荟萃分析的组成部分，旨在批判性地阅读荟萃分析报告。实例包括降脂药物和冠状动脉搭桥手术。在国立卫生研究院举办的一次研讨会上，探讨了荟萃分析在临床试验设计和监测中的作用，并对荟萃分析的这些应用方面进行了考量。本文简要回顾了荟萃分析的基本分析方法和图形方法。目的是鼓励对已发表或展示的众多荟萃分析进行更深入的评估。
