Véra P, Zilbovicius M, Chabriat H, Amarenco P, Kerdraon J, Ménard J F, Amarenco G, Bousser M G, Rancurel G, Samson Y
Frédéric Joliot Hospital, CEA-DRM, Orsay, France.
J Nucl Med. 1996 Dec;37(12):1976-81.
Fluorine-18-setoperone PET imaging was used to investigate serotonergic 5-HT2-specific binding in unlesioned cerebral cortex in stroke patients.
Seventeen stroke patients (mean age 50 +/- 31 yr) with right (n = 9) or left (n = 8) chronic stroke (middle or anterior cerebral artery territory) underwent [18F]setoperone PET and MR imaging. The distribution volume of the 5-HT2-specific binding at equilibrium (DVSe) was determined in the unlesioned cortical regions. The results were compared with those obtained in 14 age-matched controls. In addition, we investigated the effect of the side of the stroke, lesion volume and its localization.
After removing the age effect by covariance analysis, we found a significant DVSe decrease in the temporal (p < 0.05) and frontal (p < 0.05) unlesioned cortices ipsilateral to the stroke. The changes were similar in patients with left and right stroke and did not correlate with the volume of the stroke. However, the localization of the stroke affected the topography of DVSe abnormalities. When the lesion did not extend more medially than the internal capsule, DVSe was significantly reduced in the temporal lobe (-30%, p < 0.05) but not in the frontal lobe (-21%, p = ns). Conversely, when the lesion extended subcortically in the anteromedial region, close to the midline, DVSe was reduced in both temporal (-40%, p < 0.05) and frontal (- 49%, p < 0.05) lobes.
This study confirms that stroke may alter 5-HT2 receptors in large unlesioned cortical areas and that the changes depend on the subcortical extent of the lesion.
采用氟-18-司托哌隆PET成像研究中风患者未受损大脑皮质中的5-羟色胺能5-HT2特异性结合。
17例中风患者（平均年龄50±31岁），右侧（n = 9）或左侧（n = 8）慢性中风（大脑中动脉或前动脉区域），接受[18F]司托哌隆PET和磁共振成像。在未受损皮质区域测定平衡时5-HT2特异性结合的分布容积（DVSe）。将结果与14例年龄匹配的对照组所得结果进行比较。此外，我们研究了中风侧、病变体积及其定位的影响。
通过协方差分析消除年龄影响后，我们发现中风同侧颞叶（p < 0.05）和额叶（p < 0.05）未受损皮质的DVSe显著降低。左、右中风患者的变化相似，且与中风体积无关。然而，中风的定位影响了DVSe异常的地形图。当病变未向内侧延伸超过内囊时，颞叶的DVSe显著降低（-30%，p < 0.05），但额叶未降低（-21%，p = 无统计学意义）。相反，当病变在前内侧区域皮质下延伸至中线附近时，颞叶（-40%，p < 0.05）和额叶（-49%，p < 0.05）的DVSe均降低。
本研究证实中风可能改变未受损大皮质区域的5-HT2受体，且这些变化取决于病变的皮质下范围。
