猫传染性腹膜炎期间的细胞凋亡与T细胞耗竭
Apoptosis and T-cell depletion during feline infectious peritonitis.
作者信息
Haagmans B L, Egberink H F, Horzinek M C
机构信息
Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands.
出版信息
J Virol. 1996 Dec;70(12):8977-83. doi: 10.1128/JVI.70.12.8977-8983.1996.
Abstract
Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.
摘要
因感染猫冠状病毒变种而引发免疫介导疾病——猫传染性腹膜炎的猫，其淋巴器官会出现细胞凋亡和T细胞耗竭。该病症过程中产生的腹水在体外可导致细胞凋亡，但仅在活化的T细胞中出现这种情况。由于猫传染性腹膜炎病毒不会感染T细胞，且病毒蛋白也不会抑制T细胞增殖，因此我们推测，感染期间释放的可溶性介质会导致细胞凋亡和T细胞耗竭。
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