猫传染性腹膜炎期间的细胞凋亡与T细胞耗竭
Apoptosis and T-cell depletion during feline infectious peritonitis.
作者信息
Haagmans B L, Egberink H F, Horzinek M C
机构信息
Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands.
出版信息
J Virol. 1996 Dec;70(12):8977-83. doi: 10.1128/JVI.70.12.8977-8983.1996.
Abstract
Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.
摘要
因感染猫冠状病毒变种而引发免疫介导疾病——猫传染性腹膜炎的猫，其淋巴器官会出现细胞凋亡和T细胞耗竭。该病症过程中产生的腹水在体外可导致细胞凋亡，但仅在活化的T细胞中出现这种情况。由于猫传染性腹膜炎病毒不会感染T细胞，且病毒蛋白也不会抑制T细胞增殖，因此我们推测，感染期间释放的可溶性介质会导致细胞凋亡和T细胞耗竭。
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本文引用的文献
1
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells.
Nature. 1993 Apr 22;362(6422):758-61. doi: 10.1038/362758a0.
2
Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene.
Nature. 1993 Feb 25;361(6414):739-42. doi: 10.1038/361739a0.
3
Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency.
J Virol. 1993 Oct;67(10):5754-65. doi: 10.1128/JVI.67.10.5754-5765.1993.
4
Transforming growth factor-beta 2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression.
Eur J Immunol. 1994 Jun;24(6):1293-300. doi: 10.1002/eji.1830240608.
5
Thymocyte apoptosis induced by elevated endogenous corticosterone levels.
Eur J Immunol. 1994 May;24(5):1115-21. doi: 10.1002/eji.1830240516.
6
Murine retrovirus-induced depletion of T cells is mediated through activation-induced death by apoptosis.
J Virol. 1994 Apr;68(4):2735-40. doi: 10.1128/JVI.68.4.2735-2740.1994.
7
Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.
J Clin Invest. 1994 Mar;93(3):982-8. doi: 10.1172/JCI117105.
8
T-cell apoptosis detected in situ during positive and negative selection in the thymus.
Nature. 1994 Nov 3;372(6501):100-3. doi: 10.1038/372100a0.
9
Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.
J Virol. 1994 Nov;68(11):7540-5. doi: 10.1128/JVI.68.11.7540-7545.1994.
10
Macrophage-tropic HIV: critical for AIDS pathogenesis?
Immunol Today. 1994 Jul;15(7):332-9. doi: 10.1016/0167-5699(94)90081-7.
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