Mosier D, Sieburg H
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Immunol Today. 1994 Jul;15(7):332-9. doi: 10.1016/0167-5699(94)90081-7.
Human immunodeficiency virus (HIV) occurs as a number of genetic and biological variants. Of these, transmission of macrophage-tropic HIV variants appears to be favored, although most infected individuals also harbor T-cell-tropic cytopathic viruses and macrophage-tropic non-cytopathic viruses. Recent evidence regarding CD4+ T-cell depletion in vivo suggests that macrophage-tropic HIV isolates may be necessary and sufficient for the development of AIDS. This review summarizes the recent findings on macrophage-tropic viruses, and compares matched sets of experiments in HIV-infected humanized severe combined immunodeficiency (SCID) mice with a computer simulation of the lymph node microenvironment. This may help to understand why HIV infection of macrophages may have profound effects on the immune system.
人类免疫缺陷病毒（HIV）以多种基因和生物学变体的形式存在。其中，巨噬细胞嗜性HIV变体的传播似乎更为常见，不过大多数受感染个体也携带T细胞嗜性细胞病变病毒和巨噬细胞嗜性非细胞病变病毒。近期关于体内CD4+ T细胞耗竭的证据表明，巨噬细胞嗜性HIV分离株可能是艾滋病发展所必需且足够的条件。这篇综述总结了关于巨噬细胞嗜性病毒的最新发现，并将HIV感染的人源化严重联合免疫缺陷（SCID）小鼠的配对实验与淋巴结微环境的计算机模拟进行了比较。这可能有助于理解为什么巨噬细胞的HIV感染会对免疫系统产生深远影响。
