对接受药物治疗的跛行患者肌肉氧含量的客观评估。

An objective evaluation of muscle oxygen content in claudicants receiving drug therapy.

作者信息

Komiyama T, Shigematsu H, Yasuhara H, Hosoi Y, Muto T

机构信息

Department of Surgery, University of Tokyo, Japan.

出版信息

Int Angiol. 1996 Sep;15(3):215-8.

PMID:8971578

Abstract

The effects of medical treatment with a prostaglandin I2 analog (beraprost sodium) were evaluated in 19 of 120 cases studied with near-infrared spectroscopy (NIRS) from January 1993 to September 1994. The relative changes in oxygenated (Oxy) and deoxygenated (Deo) hemoglobin (Hb) in the calf muscle were measured during a treadmill walking test and the subsequent recovery period. After medical treatment in these 19 cases, recovery time of OxyHb decreased in 10 cases, increased in 7 cases and remained unchanged in two cases. Pressure studies did not facilitate the assessment of changes in the severity of claudication. Our results demonstrate that NIRS can provide objective information regarding the effects of medical therapy in claudicants.

摘要

1993年1月至1994年9月期间，我们使用近红外光谱（NIRS）对120例患者中的19例进行了研究，评估了前列腺素I2类似物（贝拉普罗斯钠）药物治疗的效果。在跑步机行走测试及随后的恢复期内，测量了小腿肌肉中氧合血红蛋白（OxyHb）和脱氧血红蛋白（DeoHb）的相对变化。这19例患者接受药物治疗后，10例患者的氧合血红蛋白恢复时间缩短，7例患者延长，2例患者不变。压力研究无助于评估间歇性跛行严重程度的变化。我们的结果表明，NIRS能够提供有关药物治疗对间歇性跛行患者疗效的客观信息。