Herrera D G, Robertson H A
Department of Neurology and Neuroscience, New York Hospital, Cornell Medical Center, NY 10021, USA.
Prog Neurobiol. 1996 Oct;50(2-3):83-107. doi: 10.1016/s0301-0082(96)00021-4.
Activation of the proto-oncogene c-fos in the brain was described initially almost a decade ago and represents one of the most studied immediate early genes in the brain. Transient c-fos expression in the central nervous system was first observed after seizure activity and following noxious stimulation in the spinal cord. Since then, multiple studies have shown that different stimuli can induce c-fos expression. Seizure activity induces rapid and transient expression of c-fos in hippocampal structures. Similarly, transient activation of c-fos follows cortical brain injury in a pattern that resembles that of spreading depression. Many other stimuli have been shown to induce the expression of this proto-oncogene in the brain and c-fos immunostaining and in situ hybridization are now used to map brain metabolism under different physiological and non-physiological conditions. Here we review the variety of inducible patterns of c-fos expression in the brain.
原癌基因c-fos在大脑中的激活最初是在近十年前被描述的，它是大脑中研究最多的即刻早期基因之一。中枢神经系统中c-fos的瞬时表达最初是在癫痫活动后以及脊髓受到有害刺激后观察到的。从那时起，多项研究表明不同的刺激可以诱导c-fos表达。癫痫活动可诱导海马结构中c-fos快速、瞬时表达。同样，c-fos的瞬时激活在皮质脑损伤后呈现出类似于扩散性抑制的模式。许多其他刺激已被证明可诱导大脑中这种原癌基因的表达，现在c-fos免疫染色和原位杂交被用于绘制不同生理和非生理条件下的脑代谢图谱。在此，我们综述了大脑中c-fos表达的各种诱导模式。
