Bosch J C, Kaashoek M J, Kroese A H, van Oirschot J T
South East Genetics, Lochem, The Netherlands.
Vet Microbiol. 1996 Oct;52(3-4):223-34. doi: 10.1016/s0378-1135(96)00070-3.
A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle. The attenuated vaccine induced the best clinical protection as evidenced by the total absence of clinical signs and fever in cattle. In addition, the attenuated vaccine reduced the shedding of challenge virus significantly more than the inactivated vaccines. Of the inactivated vaccines, the gE-negative vaccine induced a better clinical protection than the gD-subunit vaccine.
开展了一项关于3种牛疱疹病毒1型（BHV1）标记疫苗效力的比较研究。一种减毒gE阴性疫苗、一种灭活gE阴性疫苗和一种实验性gD亚单位疫苗在牛的疫苗接种-攻毒实验中进行了两次测试。减毒疫苗诱导出了最佳的临床保护效果，牛完全没有临床症状和发热就是证明。此外，减毒疫苗比灭活疫苗能更显著地减少攻毒病毒的排出。在灭活疫苗中，gE阴性疫苗诱导的临床保护效果优于gD亚单位疫苗。
