Espuny A, Carceles C M, Vicente M S, Escudero E
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, University of Murcia, Spain.
Vet Q. 1996 Dec;18(4):136-40. doi: 10.1080/01652176.1996.9694635.
Some pharmacokinetic parameters of an ampicillin/sulbactam (2:1) combination were studied in six goats, after intravenous and intramuscular injection at a single dosage of 20 mg/kg bodyweight (13.33 mg/kg of sodium ampicillin and 6.67 mg/kg of sodium sulbactam). The drugs were distributed according to an open two-compartment model. The apparent volumes of distribution calculated by the area method of ampicillin and sulbactam were 0.34 +/- 0.04 l/kg and 0.45 +/- 0.15 l/kg, respectively, and the total body clearances were 0.72 +/- 0.11 and 0.38 +/- 0.07 l/kg.h. The half-lives of ampicillin after intravenous and intramuscular administration were 0.32 +/- 0.04 h and 0.71 +/- 0.14 h, respectively. For sulbactam the half-lives were 0.79 +/- 0.18 h and 1.13 +/- 0.21 h after administration by the same routes. The bioavailability after intramuscular injection was high and similar for both drugs (98.29% for ampicillin and 101.84% for sulbactam). The mean peak plasma levels of ampicillin (0.43 +/- 0.27 h) and sulbactam (0.34 +/- 0.14 h) were reached at a similar time, and peak concentrations were also similar and non-proportional to the dose of the products administered (11.02 +/- 3.11 mg/l of ampicillin and 9.5 +/- 0.98 mg/l of sulbactam).
在6只山羊中研究了氨苄西林/舒巴坦（2:1）组合单次静脉注射和肌肉注射20mg/kg体重（13.33mg/kg氨苄西林钠和6.67mg/kg舒巴坦钠）后的一些药代动力学参数。药物按开放二室模型分布。通过面积法计算的氨苄西林和舒巴坦的表观分布容积分别为0.34±0.04l/kg和0.45±0.15l/kg，总体清除率分别为0.72±0.11和0.38±0.07l/kg·h。静脉注射和肌肉注射后氨苄西林的半衰期分别为0.32±0.04h和0.71±0.14h。舒巴坦经相同途径给药后的半衰期分别为注射后0.79±0.18h和1.13±0.21h。肌肉注射后的生物利用度较高，两种药物相似（氨苄西林为98.29%，舒巴坦为101.84%）。氨苄西林（0.43±0.27h）和舒巴坦（0.34±0.14h）的平均血浆峰浓度在相似时间达到，峰浓度也相似且与给药产品剂量不成比例（氨苄西林为11.02±3.11mg/l，舒巴坦为9.5±0.98mg/l）。
