Tavani A, Pregnolato A, La Vecchia C, Negri E, Favero A, Franceschi S
Istituto di Ricerhe Farmacologiche Mario Negri, Milan, Italy.
Eur J Cancer Prev. 1996 Oct;5(5):337-42. doi: 10.1097/00008469-199610000-00005.
The relationship between brassière size, as an indicator of breast size, and breast cancer risk was considered in a case--control study conducted between 1991 and 1994 in six Italian centres. Cases were 2,557 women, below age 75, with histologically confirmed breast cancer, and controls were 2,566 women admitted to hospital for a wide spectrum of acute, non-neoplastic, non-hormone-related diseases. Odds ratio (ORs) of breast cancer and their 95% confidence intervals (CIs) were obtained from multiple logistic regression equations including terms for study centre and age, as well as main breast cancer risk factors. A slight inverse relationship was observed between breast size and the risk of breast cancer, with an OR of 1.37 (95% CI 1.05-1.80) for the smallest brassière size compared with the largest; the increase in risk disappeared after adjustment for main recognized breast cancer risk factors, with an OR of 1.16 (95% CI 0.87-1.54) for brassière size < or = 1 compared with > or = 5. No significant heterogeneity in risk of breast cancer with breast size was found in strata of age at diagnosis, parity, age at first birth, age at menopause, family history of breast cancer, benign breast disease, ever use of oral contraceptives and/or hormone replacement therapy. Thus, this study, based on large number of caucasian women, provides conclusive evidence of a lack of appreciable association between breast size and breast cancer risk in this Italian population.
1991年至1994年期间，在意大利的六个中心开展了一项病例对照研究，探讨了作为乳房大小指标的胸罩尺寸与患乳腺癌风险之间的关系。病例组为2557名75岁以下经组织学确诊为乳腺癌的女性，对照组为2566名因各种急性、非肿瘤性、非激素相关疾病入院的女性。乳腺癌的比值比（OR）及其95%置信区间（CI）通过多因素逻辑回归方程得出，方程中纳入了研究中心、年龄以及主要的乳腺癌风险因素。研究发现乳房大小与患乳腺癌风险之间存在轻微的负相关关系，最小胸罩尺寸组与最大胸罩尺寸组相比，OR为1.37（95%CI 1.05 - 1.80）；在对主要公认的乳腺癌风险因素进行调整后，这种风险增加消失，胸罩尺寸≤1组与≥5组相比，OR为1.16（95%CI 0.87 - 1.54）。在诊断时的年龄、产次、初产年龄、绝经年龄、乳腺癌家族史、良性乳腺疾病、是否曾使用口服避孕药和/或激素替代疗法等分层中，未发现乳腺癌风险随乳房大小存在显著异质性。因此，这项基于大量白人女性的研究提供了确凿证据，表明在该意大利人群中，乳房大小与患乳腺癌风险之间不存在明显关联。
