Matee M I, Samaranayake L P, Scheutz F, Simon E, Lyamuya E F, Mwinula J
Department of Microbiology and Immunology, Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania.
APMIS. 1996 Sep;104(9):623-8.
Although biotypes of Candida albicans from adult populations, especially in the West, have been described, there are no data either from a child population, or from the African continent. Hence a total of 200 oral C. albicans isolates from Tanzanian children aged 6-24 months were biotyped using two commercially available API micromethod kit systems and a boric acid resistance test. The predominant biotypes, which comprised two thirds of the organisms isolated, were J1S (19.5%), A1S (16.0%), J1R (14.5%), A1R (9.5%) and P1R (7.5%). In total, 16 new biotypes comprising 44 (22%) isolates which have not hitherto been described were found in this Tanzanian population and, of these, the P1R biotype predominated with 15 (7.5%) isolates. There was no significant association between predominant biotypes (with clusters > or = 15 isolates) and age, gender, breast feeding and malnutrition. These data indicate that the biotype profile of C. albicans isolates may differ in paediatric and adult populations, and/or global distribution of various subtypes of this common opportunistic pathogen.
虽然已经描述了来自成人人群（尤其是西方）的白色念珠菌生物型，但尚无来自儿童人群或非洲大陆的数据。因此，使用两种市售的API微量方法试剂盒系统和硼酸抗性试验，对来自坦桑尼亚6至24个月大儿童的200株口腔白色念珠菌分离株进行了生物分型。主要生物型占分离出的生物体的三分之二，分别为J1S（19.5%）、A1S（16.0%）、J1R（14.5%）、A1R（9.5%）和P1R（7.5%）。在这个坦桑尼亚人群中，总共发现了16种新的生物型，包括44株（22%）此前未被描述的分离株，其中P1R生物型占主导，有15株（7.5%）。主要生物型（聚类≥15株）与年龄、性别、母乳喂养和营养不良之间没有显著关联。这些数据表明，白色念珠菌分离株的生物型谱在儿科和成人人群中可能不同，和/或这种常见机会性病原体的各种亚型的全球分布也可能不同。
