Chabot B
Departement De Microbiologie et Infectiologie, Faculté De Médecine, Université De Sherbrooke, Québec, Canada.
Trends Genet. 1996 Nov;12(11):472-8. doi: 10.1016/0168-9525(96)10037-8.
Recent progress in the study of alternative RNA splicing indicates that the interaction of RNA-binding proteins with specific target elements modulates splice site recognition and spliceosome assembly. The identity of splicing signals, the presence of modulating elements and differences in the distribution of RNA-binding proteins are key determinants involved in the tissue-specific regulation of splice site selection.
RNA可变剪接研究的最新进展表明，RNA结合蛋白与特定靶元件的相互作用可调节剪接位点识别和剪接体组装。剪接信号的特性、调节元件的存在以及RNA结合蛋白分布的差异是参与剪接位点选择组织特异性调控的关键决定因素。
