[前列腺素F2α和E2对大鼠促黄体生成素分泌的影响（作者译）]

[Effect of administering prostaglandine f2alpha and e2 on lh secretion in rat (author's transl)].

作者信息

Tresguerres J A, Fernández-Galaz M C, Martínez-Guarro M, Oriol-Bosch A

出版信息

Rev Esp Fisiol. 1977 Sep;33(3):205-9.

Abstract

Intraperitoneal administration of 100 ng of synthetic LH-RH to castrated male rats, produces a significant elevation of plasma LH values, as determined by RIA. A greater increase is obtained, by administrating 400 ng of LH-RH. Intrayugular injection of physiologic saline reduces basal values of plasma LH. This pattern is not modified by administration of 10 microgram or 100 microgram of PGF2alpha. On the other hand 10 microgram of PGE2 compensates the fall and 100 microgram significantly increases plasma LH over the basal values. Intracarotidly a similar pattern is observed. Plasma LH values decreases in the control group and no modification is observed by the administration of 10 microgram of PGF2alpha. By injecting the same amount of PGE2, plasma LH values remains constant, compensating the fall observed in the controls. Our results show a stimulatory effect of PGE2 and no effect of PGF2alpha on LH secretion in the castrated male rat.

摘要

对去势雄性大鼠腹腔注射100纳克合成促黄体激素释放激素（LH-RH），通过放射免疫分析（RIA）测定，可使血浆LH值显著升高。注射400纳克LH-RH可获得更大幅度的升高。颈内注射生理盐水可降低血浆LH的基础值。给予10微克或100微克前列腺素F2α（PGF2α）不会改变这种模式。另一方面，10微克前列腺素E2（PGE2）可补偿这种下降，而100微克则可使血浆LH值显著高于基础值。经颈动脉注射也观察到类似模式。对照组血浆LH值下降，给予10微克PGF2α未观察到改变。注射相同剂量的PGE2，血浆LH值保持恒定，补偿了对照组中观察到的下降。我们的结果表明，PGE2对去势雄性大鼠的LH分泌有刺激作用，而PGF2α无作用。